NO PAIN IS A PATIENT’S GAIN – A REVIEW OF SURGICAL TECHNIQUES FOR PREVENTION AND TREATMENT OF POSTAMPUTATION PAIN

Authors

  • Gordana Georgieva University Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Gjorgje Dzokikj University Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Boro Dzonov University Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Sofija Pejkova University Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia

Keywords:

phantom limb pain, RPNI, neuroma, residual limb pain, amputation

Abstract

Regardless of the cause, major lower limb amputation is a life-changing event and accompanied by pain it has a great impact on patients’ quality of life. Over the years many pharmacological and surgical treatments have been tried to manage residual limb pain and phantom limb pain, but they were either unsuccessful or did not apply to all patients. The aim of this review paper was to describe the current modalities of treatment of postamputation pain and the opportunity to use surgical techniques as prophylactic. More than 150 surgical interventions have been described in the literature: traction neurectomy, nerve capping, end-to-end nerve coaptation, nerve transposition, etc. New and efficient techniques are regenerative peripheral nerve interface and targeted muscle reinnervation initially described for bioprosthetic control. Results from recent studies have shown that these techniques can be used for treatment, but also in a prophylactic manner, which can only be of benefit for the patient. 

References

de Lange JWD, Hundepool CA, Power DM, Rajaratnam V, Duraku LS, Zuidam JM. Prevention is better than cure: Surgical methods for neuropathic pain prevention following amputation - A systematic review. J Plast Reconstr Aesthet Surg 2022; 75(3): 948-959. doi: 10.1016/j.bjps.2021.11.076.

Loewenstein SN, Cuevas CU, Adkinson JM. Utilization of Techniques for Upper Extremity Amputation Neuroma Treatment and Prevention. J Plast Reconstr Aesthet Surg 2022; 75(5): 1551-1556. doi: 10.1016/j.bjps.2021.11.077.

Nikolajsen L. Postamputation pain: studies on mechanisms. Dan Med J 2012; 59 (10): B4527. PMID: 23158899.

Schley MT, Wilms P, Toepfner S, Schaller HP, Schmelz M, Konrad CJ, et al. Painful and nonpainful phantom and stump sensations in acute traumatic amputees. J Trauma 2008; 65(4): 858-864. doi: 10.1097/TA.0b013e31812eed9e.

Limakatso K, Bedwell GJ, Madden VJ, Parker R. The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis. PLoS One 2020; 15(10): e0240431. doi: 10.1371/journal.pone.0240431.

Woodhouse A. Phantom limb sensation. Clin Exp Pharmacol Physiol 2005; 32(1-2): 132-134. doi: 10.1111/j.1440-1681.2005.04142.x.

Bosmans JC, Geertzen JH, Post WJ, van der Schans CP, Dijkstra PU. Factors associated with phantom limb pain: a 31/2-year prospective study. Clin Rehabil 2010; 24(5): 444-53. doi: 10.1177/0269215509360645.

Neumeister MW, Winters JN. Neuroma. Clin Plast Surg 2020; 47(2): 279-283. doi: 10.1016/j.cps.2019.12.008.

Vernadakis AJ, Koch H, Mackinnon SE. Management of neuromas. Clin Plast Surg 2003; 30(2): 247-268, vii. doi: 10.1016/s0094-1298(02)00104-9.

Laing T, Siddiqui A, Sood M. The management of neuropathic pain from neuromas in the upper limb: surgical techniques and future directions. Plast Aesthet Res 2015;2:165-70. http://dx.doi.org/10.4103/2347-9264.160879

Kooijman CM, Dijkstra PU, Geertzen JHB, Elzinga A, van der Schans CP. Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain 2000; 87(1): 33-41. doi: 10.1016/S0304-3959(00)00264-5.

Clark RL, Bowling FL, Jepson F, Rajbhandari S. Phantom limb pain after amputation in diabetic patients does not differ from that after amputation in nondiabetic patients. Pain 2013; 154(5): 729-732. doi: 10.1016/j.pain.2013.01.009.

Ganesh Kumar N, Kung TA. Regenerative Peripheral Nerve Interfaces for the Treatment and Prevention of Neuromas and Neuroma Pain. Hand Clin 2021; 37(3): 361-371. doi: 10.1016/j.hcl.2021.05.003.

Santosa KB, Oliver JD, Cederna PS, Kung TA. Regenerative Peripheral Nerve Interfaces for Prevention and Management of Neuromas. Clin Plast Surg 2020; 47 (2): 311-321. doi: 10.1016/j.cps.2020.01.004.

Issa CJ, Svientek SR, Dehdashtian A, Cederna PS, Kemp SWP. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open 2022; 10(9): e4549. doi: 10.1097/GOX.0000000000004549.

Eberlin KR, Ducic I. Surgical Algorithm for Neuroma Management: A Changing Treatment Paradigm. Plast Reconstr Surg Glob Open 2018; 6(10): e1952. doi: 10.1097/GOX.0000000000001952.

Norbert Kang, Alexander Woollard, Wojciech Konczalik, New surgical options to improve the quality of life of amputees, Surgery (Oxford), 2019; 37(5): 276-287. doi: 10.1016/j.mpsur.2019.02.007.

Bowen JB, Wee CE, Kalik J, Valerio IL. Targeted Muscle Reinnervation to Improve Pain, Prosthetic Tolerance, and Bioprosthetic Outcomes in the Amputee. Adv Wound Care (New Rochelle) 2017; 6(8): 261-267. doi: 10.1089/wound.2016.0717.

Dellon AL, Aszmann OC. In musculus, veritas? Nerve "in muscle" versus targeted muscle reinnervation versus regenerative peripheral nerve interface: Historical review. Microsurgery 2020; 40(4): 516-522. doi: 10.1002/micr.30575.

Gstoettner C, Laengle G, Salminger S, Festin C, Platzgummer H, Aszmann OC. Der chirurgische Umgang mit peripheren Nerven nach Extremitätenverlust [Surgical management of peripheral nerves after extremity loss]. Orthopade 2021; 50(1): 14-23. German. doi: 10.1007/s00132-020-04032-1.

Mioton LM, Dumanian GA. Targeted muscle reinnervation and prosthetic rehabilitation after limb loss. J Surg Oncol 2018; 118(5): 807-814. doi: 10.1002/jso.25256.

Collins KL, Russell HG, Schumacher PJ, Robinson-Freeman KE, O'Conor EC, Gibney KD, et al. A review of current theories and treatments for phantom limb pain. J Clin Invest 2018; 128(6): 2168-2176. doi: 10.1172/JCI94003.

Modest JM, Raducha JE, Testa EJ, Eberson CP. Management of Post-Amputation Pain. R I Med J 2020;103(4): 19-22.

Lanier ST, Jordan SW, Ko JH, Dumanian GA. Targeted Muscle Reinnervation as a Solution for Nerve Pain. Plast Reconstr Surg 2020; 146(5): 651e-663e. doi: 10.1097/PRS.0000000000007235.

Kubiak CA, Kemp SWP, Cederna PS, Kung TA. Prophylactic Regenerative Peripheral Nerve Interfaces to Prevent Postamputation Pain. Plast Reconstr Surg 2019; 144(3): 421e-430e. doi: 10.1097/PRS.0000000000005922.

Hooper RC, Cederna PS, Brown DL, Haase SC, Waljee JF, Egeland BM, et al. Regenerative Peripheral Nerve Interfaces for the Management of Symptomatic Hand and Digital Neuromas. Plast Reconstr Surg Glob Open 2020; 8(6): e2792. doi: 10.1097/GOX.0000000000002792.

Woo SL, Kung TA, Brown DL, Leonard JA, Kelly BM, Cederna PS. Regenerative Peripheral Nerve Interfaces for the Treatment of Postamputation Neuroma Pain: A Pilot Study. Plast Reconstr Surg Glob Open 2016; 4(12): e1038. doi: 10.1097/GOX.0000000000001038.

Kubiak CA, Adidharma W, Kung TA, Kemp SWP, Cederna PS, Vemuri C. "Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)". Ann Vasc Surg 2022; 79: 421-426. doi: 10.1016/j.avsg.2021.08.014.

Hoyt BW, Potter BK, Souza JM. Nerve Interface Strategies for Neuroma Management and Prevention: A Conceptual Approach Guided by Institutional Experience. Hand Clin 2021; 37(3): 373-382. doi: 10.1016/j.hcl.2021.05.004.

Kurlander DE, Wee C, Chepla KJ, Lineberry KD, Long TC, Gillis JA, et al. TMRpni: Combining Two Peripheral Nerve Management Techniques. Plast Reconstr Surg Glob Open 2020; 8(10): e3132. doi: 10.1097/GOX.0000000000003132.

Eberlin KR. Discussion: Prophylactic Regenerative Peripheral Nerve Interfaces to Prevent Postamputation Pain. Plast Reconstr Surg 2019; 144(3): 431e-432e. doi: 10.1097/PRS.0000000000005923.

Kadota H, Ishida K. Coaptation of Cutaneous Nerves for Intractable Stump Pain and Phantom Limb Pain after Upper Limb Amputation. Strategies Trauma Limb Reconstr 2020; 15(1): 50-53. doi: 10.5005/jp-journals-10080-1442.

Economides, JM, DeFazio MV, Attinger CE, Barbour JR. Prevention of Painful Neuroma and Phantom Limb Pain After Transfemoral Amputations Through Concomitant Nerve Coaptation and Collagen Nerve Wrapping. Neurosurgery 2016; 79(3): 508-513. doi: 10.1227/NEU. 0000000000001313.

Dellon AL, Mackinnon SE. Treatment of the painful neuroma by neuroma resection and muscle implantation. Plast Reconstr Surg 1986; 77(3): 427-438. doi: 10.1097/00006534-198603000-00016.

Ducic I, Mesbahi AN, Attinger CE, Graw K. The role of peripheral nerve surgery in the treatment of chronic pain associated with amputation stumps. Plast Reconstr Surg 2008; 121(3): 908-914. doi: 10.1097/01.prs.0000299281.57480.77.

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Published

2022-12-20

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Section

Review Article