OVARIAN DYSGERMINOMA IN PREGNANCY

Authors

  • Deva Petrova Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia Clinical Hospital Acibadem Sistina, Skopje, Rеpublic of North Macedonia https://orcid.org/0009-0008-6802-6430
  • Katerina Kubelka-Sabit Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia Clinical Hospital Acibadem Sistina, Skopje, Rеpublic of North Macedonia https://orcid.org/0000-0002-3941-2219
  • Kornelija Trajkova Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia Clinical Hospital Acibadem Sistina, Skopje, Rеpublic of North Macedonia https://orcid.org/0009-0001-1870-6672
  • Dzengis Jashar Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia Clinical Hospital Acibadem Sistina, Skopje, Rеpublic of North Macedonia https://orcid.org/0000-0002-8435-5882

Keywords:

ovarian dysgerminoma, pregnancy, conservative surgery

Abstract

Dysgerminoma is a very rare germ cell tumor of the ovary. It constitutes about 1% of all germ cell malignancies and accounts for 1-5% of all ovarian malignancies in the first two decades of life. Approximately 80% of cases are reported in patients younger than 30 years of age (mean age: 21 years), whereas 75% of women with dysgerminomas present with stage I of the disease. Ovarian tumors generally remain asymptomatic, until they are discovered due to their large size or related complications.

Dysgerminomas can occur in pregnant women. Тhe most commonly used diagnostic methods for ovarian tumors in pregnancy are ultrasound and magnetic resonance, not using radiation for ensuring safety of the fetus. Several factors have influence on treatment decisions such as: gestational week of the pregnancy, patient’s expectations, stage of the disease, influence of the diagnostic methods for assessing the stage of the disease on the fetus, as well as the reproductive history of the patient. In stage I of the disease, fertility sparing surgery with unilateral salpingo-oophorectomy can be performed if the patient wants to preserve fertility. No chemotherapy is required for stage I tumors, unless recurrence occurs (9.2% cases).

We present a case of dysgerminoma in a pregnant patient, treated with unilateral salpingo-oophorectomy. After two years of follow-up, the patient remained free of disease.

References

Smith HO, Berwick M, Verschraegen CF, Wiggins C, Lansing L, Muller CY, Qualls CR. Incidence and survival rates for female malignant germ cell tumors. Obstet Gynecol. 2006 May;107(5):1075-85. doi: 10.1097/01.AOG.0000216004.22588.ce. PMID: 16648414.

Anwar S, Rehan B, Hameed G. MRI for the diagnosis of ultrasonographically indeterminate pelvic masses. J Pak Med Assoc. 2014;64(2):171–4.

Quirk JT, Natarajan N. Ovarian cancer incidence in the United States, 1992–1999. Gynecol Oncol. 2005;97(2):519–23

Gupta M, Saini V. Germ cell tumors and their association with pregnancy. In: Ahmed RG, editor. Germ Cell. IntechOpen; 2017.

Sas I, Serban D, Tomescu L, Nicolae N. Ovarian dysgerminoma in pregnancy: A case report. Medicine 2021; 100: e25364

Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO. Ovarian malignant germ cell tumors: Cellular classification and clinical and imaging features. Radiographics. 2014;34(3):777-801.

Kitajima K, Hayashi M, Kuwata Y. MRI appearances of ovarian dysgerminoma. Eur J Radiol Extra 2007;61:23–5.

Jain M, Budhwani C, Jain AK, Hazari RA. Pregnancy with ovarian dysgerminoma: an unusual diagnosis. J Dent Med Sci 2013;11:53–7.

Chen Y, Luo Y, Han C, Tian W, Yang W, Wang Y, Xue F. Ovarian dysgerminoma in pregnancy: A case report and literature review. Cancer Biol Ther 2018; 19: 649–658.

Matsuyama T, Tsukamoto N, Matsukuma K, Kamura T, Kaku T, Saito T. Malignant ovarian tumors associated with pregnancy: report of six cases. Int J Gynaecol Obstet 1989. Jan;28(1):61-66 10.1016/0020-7292(89)90545-6

Karlen JR, Akbari A, Cook WA. Dysgerminoma associated with pregnancy. Obstet Gynecol 1979;53:330–5.

Thomas GM, Dembo AJ, Hacker NF, DePetrillo AD. Current therapy for dysgerminoma of the ovary. Obstet Gynecol 1987:70 (2): 268-75.

AL Husaini H, Soudy H, El Din Darwish A, Ahmed M, Eltigani A, AL Mubarak M. et al. Pure dysgerminoma of the ovary: a single institutional experience of 65 patients. Med Oncol 2012.

Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 2000;70:209–62. .

Zaghloul MS, Khattab TY. Dysgerminoma of the ovary: good prognosis even in advanced stages. Int J Radiat Oncol Biol Phys. 1992;24(1):161-5. doi: 10.1016/0360-3016(92)91036-m. PMID: 1512152.

Downloads

Published

2023-12-27

Issue

Section

Case Reports