• Vlatko Kokolanski Faculty of Dentistry, Skopje, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Marijana Danevska Agency for Medicines and Medical Devices, Skopje, Republic of North Macedonia
  • Kjiro Ivanovski Faculty of Dentistry, Skopje, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Julijana Nikolovska 1Faculty of Dentistry, Skopje, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Spiro Spasovski Faculty of Dentistry, Skopje, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Bojan Poposki Faculty of Dentistry, Skopje, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia


pharmacovigilance, knowledge, healthcare professionals


Introduction: The higher incidence of adverse drug reactions (ADR) is a global health problem which requires the attention of all stakeholders. Spontaneous ADR reporting system is a global phenomenon, and the cornerstone of pharmacovigilance activities. Therefore, healthcare professionals play a crucial role in the pharmacovigilance system.

The aim of our study was to evaluate the health workers’ knowledge about pharmacovigilance in the Republic of North Macedonia

Material and method: This study included 400 health workers (100 doctors of medicine, 100 doctors of dental medicine, 100 pharmacists and 100 medical nurses/technicians) employed in public and private healthcare institutions in the city of Skopje. The research was conducted using an anonymous survey questionnaire and the collected data were statistically analyzed using SPSS Statistica v23 for Windows.

Results: Our results showed that pharmacists' knowledge was significantly better than that of other healthcare professionals regarding the definition of the term “pharmacovigilance”, the main goal of the pharmacovigilance, the obligations for reporting adverse drug reactions and the function of the system of pharmacovigilance in our country. In our study, doctors of medicine, although with weaker knowledge than pharmacists, showed a good level of knowledge of the pharmacovigilance system, while doctors of dentistry and nurses/technicians had the least knowledge of this system.

Conclusion: We believe that by predicting the curricula on pharmacovigilance and the adverse drug reactions in the undergraduate studies, adequate knowledge of this system will be provided which will contribute to improving the quality of care for patients and reducing the under-reporting of ADRs.


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