LEVELS OF C-REACTIVE PROTEIN IN PREDICTION OF PREECLAMPSIA
Keywords:
CRP, Preeclampsia, blood pressureAbstract
Preeclampsia is the cause of significant maternal and fetal morbidity and mortality. C-reactive protein is considered a sensitive inflammatory marker and its values increase in response to inflammation that occurs during tissue injury. The level of C-reactive protein increases, correlating with the severity of the clinical picture of preeclampsia.
To determine the level of C-reactive protein in patients with preeclampsia and the correlation of the value with the severity of the clinical picture of preeclampsia.
This study included 25 patients with a moderate form of preeclampsia, 25 patients with severe preeclampsia and 30 patients without symptoms, with normal pregnancy. All women were in the third trimester of pregnancy, hospitalized at the University Clinic for Gynecology and Obstetrics, Skopje, in the Department of preeclampsia, intrauterine growth retardation and premature births. Patients were examined in the period from 01.10.2022 to 10.04.2023. The severity of preeclampsia was determined by blood pressure, 24-hour proteinuria, and laboratory tests characteristic of preeclampsia.
The results obtained showed that increased CRP levels were statistically significant (p<0.001) in the serum of patients with moderately severe form of preeclampsia (group A) (mean value 8.4 mg/L; 6.1-11.3 mg/L) and severe preeclampsia (group B) (mean value 30.2 mg/L; 13-54 mg/L) in correlation with the control group (group C) (mean value 2.5 mg/L; 0.2-4.5 mg/L). There was a significant correlation between serum CRP levels and systolic blood pressure (p<0.001) and proteinuria (p<0.001).
High levels of serum CRP correlate with the severity of the clinical picture of preeclampsia.
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