INEFFECTIVE ERYTHROPOIESIS IN PATIENT WITH BETA-THALASSEMIA AND MYELODYSPLASTIC SYNDROME - CASE REPORT
Keywords:
Ineffective erythropoiesis, beta-Thalassemia, myelodysplastic syndromes, 5q deletion.Abstract
Ineffective erythropoiesis and associated anemia are hallmarks of two hematological diseases - myelodysplastic syndromes and thalassemia, treated with regular blood transfusions. Erythropoiesis is a highly regulated process where functional erythrocytes are produced from hematopoietic stem cells, and defects can adversely affect the proliferation, differentiation, and survival of erythroid precursors. Treatments that directly mark the ineffective erythropoiesis are limited. There is unmet requirement for treatments that can restore effective erythropoiesis. Herein, we present a case report of a patient with beta-thalassemia and development of myelodysplastic syndrome with 5q deletion.
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