• Arbana Rexhepi Department of Neurology, Clinical Center, Tetovo, Republic of North Macedonia
  • Anita Arsovska University Clinic for Neurology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia


acute ischemic stroke, clinical and laboratory characteristics, COVID-19 infection, COVID-19 pneumonia


Introduction: COVID-19 is closely linked to coagulopathy and consequently thromboembolism, thus increasing the probability for development of ischemic strokes.

Aim: The purpose of our study was to evaluate the clinical, laboratory and neuroimaging characteristics as well as outcome in patients with COVID-19 who developed acute ischemic stroke (AIS), hospitalized at the COVID Center at the University Clinic for Neurology in Skopje, N. Macedonia during the period of November 2020 - March 2021.

Material and methods: We conducted a retrospective analysis of ten patients with acute ischemic stroke, out of 566 COVID-19 patients hospitalized at the COVID Center at the University Clinic for Neurology in Skopje, N. Macedonia. during the period of November 2020 - March 2021 Demographic characteristics, level of consciousness, stroke type, region and volume, presence of hemorrhagic transformation and mass effect, comorbidities, level of D-dimer and inflammatory markers, presence of pneumonia and outcome of the patients were analyzed.

Results: Majority of patients developed ischemic strokes secondary to large-vessel occlusion in the anterior circulation and only one patient had posterior circulation stroke. Three patients developed massive stroke with hemorrhagic transformation and mass effect. Seven patients developed COVID-19 associated pneumonia.

Conclusion: Acute ischemic stroke in patients with COVID-19 is more likely to occur in elderly patients with cardiovascular comorbidities. Aging, comorbidities, impaired level of consciousness and increased level of D-dimer and CRP on admission along with COVID-19 pneumonia contribute to the fatal outcome.


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Original Articles