CURRENT SITUATION IN CHEMOPROPHYLAXIS AND THERAPEUTIC TREATMENT OF COVID-19
Keywords:
SARS-CoV-2 infection, COVID-19, pandemic, World Health Organization, National Institute of Health, monoclonal antibodiesAbstract
Two years have passed since the emergence of SARS-CoV-2 infection and even after all this time medical approach in prophylaxis and treatment of COVID-19 is still very relevant. The search for a magical drug which would be a game changer and which would significantly change the clinical course and the outcome of the disease continues with undiminished intensity but also with a great dose of reservation that this search can last for a long time. Until then, it is necessary to use the current knowledge based on conducted trials and gained experiences. Based on this premises, many relevant health organizations, institutions, universities and medical societies worldwide have developed appropriate guidelines for treatment of COVID-19, which are subjected to periodic updates based on the newest discoveries. Following these guidelines, the treatment of COVID-19 patients has been improved in many ways and very good results have been achieved at this time, which unfortunately is far from the best. This paper sublimates the current guidelines issued from respectable health authorities (organizations, institutions, universities and societies) based on the newest studies and meta-analyses which have been subjected to the most rigorous, strict, critical and competent review processes.
References
University of Washington. Medicine interim Treatment Guidelines for SARS-CoV-2 Infection/COVID-19. https://www.uwmedicine.org/coronavirus (last updated Feb 11, 2022).
Agarwal A, Rochwerg B, Lamontagne F, Siemieniuk RAC, Agoritsas T, Askie L, et al. A living WHO guideline on drugs for covid-19. BMJ 2020; 370: m3379 http:// dx.doi.org/10.1136/bmj.m3379.
Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, et al. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. https://www.idsociety.org/ practice-guideline/covid-19-guideline-treatment-and-management (last updated March 9, 2022).
NIH COVID-19 Treatment Guidelines. https://www.covid19treatmentguidelines.nih. gov/(last updated March 18, 2022).
Bosilkovski M. Some aspects of COVID-19 treatment – current recommendations and our observations. Macedonian medical review 2021; 75: 49-59.
WHO management World Health Organization. Living guidance for clinical management of COVID-19, 23 November 2021 https://www.who.int/publications/ i/item/WHO-2019-nCoV-clinical-2021-2.
V.18 UCSF Adult COVID-19 Management Guidelines. 3.11.22. Owner: Care Delivery Committee. (last updated March 11, 2022).
Bosilkovski M, Dimzova M, Poposki K, Petrusevska A, Markovska M, Dervisov A. Medical treatment of COVID-19: updated knowledge and actual recommendations. Vox medici 2021; 111: 638-641.
COVID-19 Guidelines Dashboard - Open Critical Care. https://opencriticalcare.org ›
covid-dashboard/ (last updated March 11, 2022).
McIntosh K. COVID-19: Epidemiology, virology, and prevention. Available from UpToDate, Waltham, MA. https://www.uptodate.com/contents/covid-19-epidemiology-virology- and-prevention (last updated: Mar 01, 2022).
Gandhi RT, Malani PN, Del Rio C. COVID-19 Therapeutics for Nonhospitalized Patients. JAMA 2022; 327: 617-618. doi: 10.1001/jama.2022.0335.
Cohen P, Gebo K. COVID-19: Outpatient evaluation and management of acute illness in adults. Available from UpToDate, Waltham, MA.
https://www.uptodate.com/contents/covid-19-outpatient-evaluation-and-management-of-acute-illness-in-adults (last updated Mar 07, 2022).
Michigan medicine. University of Michigan. Guidance for treatment of COVID-19 in adults and children. http://www.med.umich.edu/asp/pdf/adult_guidelines/COVID-19-treatment. (last Revised: March/2022).
Brigham and Women’s hospital. COVID-19 Protocols. Therapeutics. https:// bwh.covidprotocols.org/protocols/therapeutics/ (last updated January 14, 2022).
Bassetti M, Giacobbe DR, Bruzzi P, Barisione E, Centanni S, Castaldo N, et al. Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP). Infect Dis Ther 2021;10:1837-1885. doi: 10.1007/s40121-021-00487-7.
van de Veerdonk FL, Giamarellos-Bourboulis E, Pickkers P, Derde L, Leavis H, van Crevel R, et al. A guide to immunotherapy for COVID-19. Nat Med 2022; 28: 39-50. doi: 10.1038/s41591-021-01643-9.
Malin JJ, Spinner CD, Janssens U, Welte T, Weber-Carstens S, Schälte G, et al. Key summary of German national treatment guidance for hospitalized COVID-19 patients: Key pharmacologic recommendations from a national German living guideline using Evidence to Decision Framework (last updated 17.05.2021). Infection 2022; 50: 93-106. doi: 10.1007/s15010-021-01645-2.
Kim AY, Gandhi RT. COVID-19: Management in hospitalized adults. Available from UpToDate, Waltham, MA. https://www.uptodate.com/contents/covid-19-management-in-hospitalized-adults (last updated Jan 24, 2022).
