METABOLIC SYNDROME IN CHILDREN WITH ASTHMA

Authors

  • Valentina Cvejoska Cholakovska Department of Pulmonology and Allergology, University Children's Clinic, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Emilija Vlaski Department of Pulmonology and Allergology, University Children's Clinic, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Vesna Velikj Stefanovska Institute of Epidemiology and Biostatistics, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Aleksandra Acevska Jovanovska Department of Hematology and Oncology, University Children's Clinic, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Olivera Jordanova Clinical Laboratory, University Children's Clinic, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Mirjana Kochova Department of Endocrinology, University Children’s Clinic, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia

Keywords:

Asthma, body mass index, children, HOMA index, metabolic syndrome, obesity, overweight

Abstract

The association between asthma and obesity is well known, with several underlying mechanisms. The aim of the study was to evaluate whether metabolic syndrome may be other underlying mechanism related to this association. The study included 112 children (73 boys and 39 girls, mean age 11.1 ± 2.4); out of them 41were overweight, 38 had asthma and a normal body mass index (BMI), and 33 were overweight asthmatics. Serum leptin, adiponectin, glycemia, insulinemia, lipid profile levels (cholesterol and triglycerides) and the homeostasis model assessment (HOMA) index were analyzed as parameters of metabolic syndrome. BMI, waist circumferences (WC), and waist to hips ratio (WHR) were measured as parameters of obesity. Levels of BMI, WC, WHR, HOMA-IR (insulin resistance), and HOMA-AD (adiponectin) were significantly higher in overweight group (p<0.001) and overweight with asthma group compared to asthma (p<0.05). Asthma group had significantly lower level of leptin (p=0.00001) and significantly higher level of glycemia (p=0.0001) compared to overweight group and also compared to overweight with asthma group (p=0.00001 and p=0.001, respectively). A strong positive correlation was observed between leptin, BMI and WC in all three groups as well as between insulinemia and BMI in overweight (r=0.384) and asthma group (r=0.603). A significant strong correlation was also found between HOMA-IR and HOMA-AD with BMI in asthma group for consequently r=620 and r=531.

Undoubtedly, there is an association with some parameters of the metabolic syndrome in childhood asthma. However, obesity has been shown to be a major driver of metabolic changes.

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Published

2022-12-20

Issue

Vol. 2 No. 2 (2022): Acad Med J

Section

Original Articles