THE ROLE OF MATRIX METALLOPROTEINASE-1 AND ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISMS IN DEVELOPMENT OF CORONARY ARTERY DISEASE

Authors

  • Marjan Boshev University Clinic for Cardiology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia https://orcid.org/0000-0002-8735-4295
  • Svetlana Stankovic University Clinic for Hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Sasho Panov Laboratory for Molecular Biology and Genomics, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Slavica Josifovska Laboratory for Molecular Biology and Genomics, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Kiril Pakovski Laboratory for Molecular Biology and Genomics, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Oliver Kalpak University Clinic for Cardiology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Antonio Georgiev University Clinic for Cardiology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Hristo Pejkov University Clinic for Cardiology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia

Keywords:

Coronary artery disease, MMP-1, eNOS, gene polymorphism

Abstract

Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide. The main pathophysiological processes involved in the development of CAD include impaired lipid metabolism, coagulation and chronic inflammation of the coronary vessel wall. There are many well-known traditional or conventional risk factors that may contribute to development of CAD like smoking cigarettes, lack of physical activity, diabetes, obesity, arterial hypertension, dyslipidemia (hypercholesterolemia), psychosocial stress etc. Nevertheless, over the last two decades there has been a significant progress in the field of genetic research and enlightening of the genetic basis of development of CAD. Certain genetic polymorphisms have been found to be linked not only to lipid metabolism and coagulation but also to inflammation and response, tissue maintenance, remodeling and degradation of the extracellular matrix. In this review article we discuss some of the most frequently studied gene polymorphisms in the development of CAD – matrix metalloproteinase-1 (MMP-1) and endothelial nitric oxide synthase (eNOS) gene polymorphisms.

References

Malinowski D, Bochniak O, Luterek-Puszyńska K, Puszyński M, Pawlik A. Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms. Genes 2023; 14(7): 1425. https://doi.org/10.3390/ genes14071425.

Kessler T, Schunkert H. Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies. JACC: Basic to Translational Science 2021; 6(7). https://doi.org/10.1016/j.jacbts.2021.04.001.

Roberts R, Chavira J, Venner E. Genetic Risk and Its Role in Primary Prevention of CAD. J Transl Genet Genom 2022; 6: 388-402. https://dx.doi.org/10.20517/jtgg.2022.07.

Khera AV, Kathiresan S. Genetics of Coronary Artery Disease: Discovery, Biology, and Clinical Translation. Nat Rev Genet 2017; 18(6): 331-344. doi:10.1038/nrg.2016.160.

Dalepiane VLN, Silvello DN, Paludo CA, Roisenberg I, Simon D. Matrix Metalloproteinase Gene Polymorphisms in Patients with Coronary Artery Disease. Genetics and Molecular Biology 2007; 30(3): 505-510. https://doi.org/10.1590/ S1415-47572007000400001.

McPherson R, Tybjaerg-Hansen A. Genetics of Coronary Artery Disease. Circ Res 2016; 118: 564-578. doi: 10.1161/CIRCRESAHA.115.306566.

Al-Koofee DAF, Mubarak SMH. Genetic Polymorphisms. The Recent Topics in Genetic Polymorphisms. IntechOpen 2019. doi: 10.5772/intechopen.88063.

Assimes TL, Roberts R. Genetics: Implications for Prevention and Management of Coronary Artery Disease. JACC 2016; 68(25): 2797-2818. doi: 10.1016/j.jacc.2016.10.039.

Bräuninger H, Krüger S, Bacmeister L, Nyström A, Eyerich K, Westermann D, et al. Matrix metalloproteinases in coronary artery disease and myocardial infarction. Basic Research in Cardiology 2023; 118: 18. https://doi.org/10.1007/s00395-023-00987-2.

Kapoor C, Vaidya S, Wadhwan V, Kaur G, Pathak A. Seesaw of matrix metalloproteinases (MMPs). J Cancer Res Ther 2016; 12(1): 28-35. doi: 10.4103/0973-1482.157337.

Niu W, Qi Y. Matrix Metalloproteinase Family Gene Polymorphisms and Risk for Coronary Artery Disease: Systemic Review and Meta-Analysis. Heart 2012; 98(20): 1483e1491. doi: 10.1136/heartjnl-2012-302085.

Ikeda U, Shimada K. Matrix Metalloproteinase and Coronary Artery Diseases. Clin Cardiol 2003; 26(2): 55-59. doi: 10.1002/clc.4960260203.

Pawlik A, Plucinska M, Kopec M, Głabowski D, Czerewaty M, Safranow K. MMP1 and MMP3 Gene Polymorphisms in Patients with Acute Coronary Syndromes. IUBMB Life 2017; 69(11): 850-855. doi:10.1002/iub.1684.

Kondapalli MS, Galimudi RK, Gundapaneni KK, Padala C, Cingeetham A, Gantala S, et al. MMP 1 circulating levels and promoter polymorphism in risk prediction of coronary artery disease in asymptomatic first degree relatives. Gene 2016; 595(1): 115-120. doi: 10.1016/j.gene.2016.09.041.

Sakowicz A, Fendler W, Lelonek M, Pietrucha T. Genetic variability and the risk ofmyocardial infarction in Poles under 45 years of age. Arch Med Sci 2010; 6(2): 160-167. doi: 10.5114/aoms.2010.13887.

Qintao C, Yan L, Changhong D, Xiaoliang G, Xiaochen L. Genetic polymorphism of matrix metalloproteinase-1 and coronary artery disease susceptibility: a case-control study in a Han Chinese population. Genet Test Mol Biomarkers 2014; 18(12): 826-831. doi: 10.1089/gtmb.2014.0222.

Ghaffarzadeh A, Bagheri M, Khadem-Vatani K, Abdi Rad I. Association of MMP-1 (rs1799750)-1607 2G/2G and MMP-3 (rs3025058)-1612 6A/6A Genotypes with Coronary Artery Disease Risk Among Iranian Turks. J Cardiovasc Pharmacol 2019; 74(5): 420-425. doi: 10.1097/FJC.0000000000000727.

Rai H, Parveen F, Kumar S, Kapoor A, Sinha N. Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms with Coronary Artery Disease: An Updated Meta-Analysis and Systematic Review. PLoS ONE 2014; 9(11): e113363. doi: 10.1371/journal.pone.0113363.

Colombo MG, Paradossi U, Andreassi MG, Botto N, Manfredi S, Masetti S, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem 2003; 49(3): 389-395. doi: 10.1373/49.3.389.

Jaishankar T, Shivasekar M, Mohanakrishnan VV. eNOS Gene Variants and Their Genetic Susceptibility Associated with Coronary Heart Disease. J Health Sci Med Res 2023; 41(1): e2022885. doi: 10.31584/jhsmr.2022885.

El Saied AM, El Wakf AM, Elmougy R, El Hafez AA, Hussien SM. Lack of Association between Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease among Egyptian Population. International Journal of Biochemistry Research & Review 2016; 11(2): 1-12, doi: 10.9734/IJBCRR/2016/23818.

Meroufel D, Médiène-Benchekor S, Dumont J, Benhamamouch S, Amouyel P, Brousseau T. Relationship between endothelial nitric oxide synthase gene polymorphisms and the risk of myocardial infarction in the Algerian population. Egypt J Med Hum Genet 2009; 10(1).

Balci S, Yildiz PO, Sucu N, Yilmaz DC, Tamer L. T786C and G894T eNOS polymorphisms as a risk assessment of coronary artery disease. J Cardiol Curr Res 2017; 8(4): 1-6. doi: 10.15406/jccr.2017.08.00290.

Tangurek B, Ozer N, Sayar N, Terzi S, Yilmaz H, Dayi SU, et al. The relationship between endothelial nitric oxide synthase gene polymorphism (T-786C) and coronary artery disease in the Turkish population. Heart Vessels 2006; 21(5): 285-290. doi: 10.1007/s00380-005-0902-0.

Bhutani N, Tangadi D, Bhavsar P. Role of Endothelial Nitric Oxide Synthase (T-786C) Gene Polymorphism in the Development of Coronary Artery Disease. Galore International Journal of Health Sciences and Research 2020; 5(1). P-ISSN: 2456-9321.

Alkharfy KM, Al-Daghri NM, Al-Attas OS, Alokail MS, Draz HM, Hussain T. Endothelial nitric oxide synthase gene polymorphisms (894G > T and -786T > C) and risk of coronary artery disease in a Saudi population. Arch Med Res 2010; 41(2): 134-141. doi: 10.1016/j.arcmed.2010.02.004.

Rossi GP, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 2003; 41(6): 930-937. doi: 10.1016/s0735-1097(02)03012-7.

Liu D, Jiang Z, Dai L, Zhang X, Yan C, Han Y. Association between the - 786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: a systematic review and meta-analysis. Gene 2014; 545(1): 175-183. doi: 10.1016/j.gene.2013.09.099.

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Published

2024-07-09

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Review Article