RESOLUTION OF PEDIATRIC NOCTURNAL RESPIRATORY DISTRESS DUE TO UNDIAGNOSED ASTHMA: A CASE REPORT

Authors

  • Adrijana Ugrinoska Pandeva Public Health Institution University Clinic for Respiratory Diseases in Children Kozle, Skopje, Republic of North Macedonia
  • Vesna Dzambazovska Public Health Institution University Clinic for Respiratory Diseases in Children Kozle, Skopje, Republic of North Macedonia
  • Katerina Boshkovska Public Health Institution University Clinic for Respiratory Diseases in Children Kozle, Ss. Cyril and Methodius University, Faculty of Medicine, Skopje, Republic of North Macedonia

Keywords:

Pediatric asthma, nocturnal symptoms, polygraphy, spirometry, inhaled corticosteroids, sleep disturbance

Abstract

Introduction: Sleep disturbances in children may result from a range of medical or behavioral causes, with asthma often overlooked when symptoms are limited to nighttime. Asthma with atypical presentation, manifesting predominantly as nocturnal respiratory symptoms, is common but frequently misdiagnosed due to absence of daytime symptoms.

Case Report: A 10-year-old boy presented with a two-year history of nightly dry cough, dyspneic episodes, and distress. ENT evaluation revealed allergic rhinitis, and allergen testing confirmed sensitization to environmental allergens. Despite treatment with nasal corticosteroids and antihistamines, symptoms persisted. Overnight polygraphy showed significant nocturnal hypoxemia. Spirometry with bronchodilator testing confirmed reversible airway obstruction. Initiation of inhaled corticosteroid therapy led to complete and sustained resolution of symptoms.

Conclusions: This case illustrates how asthma with atypical presentation can mimic primary sleep disorders. Comprehensive respiratory evaluation, including spirometry, is essential for accurate diagnosis. Early initiation of inhaled therapy can result in rapid clinical improvement and reduce unnecessary investigations.

References

Kaditis AG, Alonso Alvarez ML, Boudewyns A, Alexopoulos EI, Ersu R, Joosten K, et al. Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management. Eur Respir J 2016; 47(1): 69-94. doi: 10.1183/13993003.00385-2015

GINA Report 2024. Global Strategy for Asthma Management and Prevention. www.ginasthma.org.

Prasad B, Nyenhuis SM, Weaver TE. Obstructive sleep apnea and asthma: associations and treatment implications. Sleep Med Rev 2014; 18(2): 165-171. doi: 10.1016/j.smrv.2013.04.004.

Puthalapattu S, Ioachimescu OC. Asthma and obstructive sleep apnea: clinical and pathogenic interactions. J Investig Med 2014; 62(4): 665-675. doi: 10.2310/JIM.0000000000000065.

Zhang A, Fagnano M, Frey SM, Halterman JS. The relationship between teen-reported nocturnal asthma symptoms and daily functioning. J Asthma 2022; 59(9): 1878-1884. doi: 10.1080/02770903.2021.1968426.

Ginsberg D. An unidentified monster in the bed--assessing nocturnal asthma in children. Mcgill J Med 2009; 12(1): 31-38. PMID: 19753285.

Weinberger M, Abu-Hasan M. Pseudo-asthma: when cough, wheezing, and dyspnea are not asthma. Pediatrics 2007; 120(4): 855-864. doi: 10.1542/peds.2007-0078.

oinis-Mitchell D, Craig T, Esteban CA, Klein RB. Sleep and allergic disease: a summary of the literature and future directions for research. J Allergy Clin Immunol 2012; 130(6): 1275-1281. doi: 10.1016/j.jaci.2012.06.026.

Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, et al. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol 2016; 138(6): 1608-1618.e12. doi: 10.1016/j.jaci.2016.09.028.

Gupta S, Lodha R, Kabra SK. Asthma, GERD and Obesity: Triangle of Inflammation. Indian J Pediatr 2018; 85(10): 887-892. doi: 10.1007/s12098-017-2484-0.

Thakkar K, Boatright RO, Gilger MA, El-Serag HB. Gastroesophageal reflux and asthma in children: a systematic review. Pediatrics. 2010 Apr;125(4):e925-30. doi: 10.1542/peds.2009-2382.

Downloads

Published

2025-12-16

Issue

Section

Case Reports