IMPACT OF INSULIN SENSITIZERS ON ANTI-MÜLLERIAN HORMONE IN POLYCYSTIC OVARY SYNDROME
Keywords:
PCOS, insulin senzitisers, Metformin, Myoinositol, Anti-Mullerian hormoneAbstract
Introduction: Elevated AMH level is considered an indicator of anovulation in PCOS. It is postulated that the use of insulin sensitizers will lead to a reduction in insulin resistance, hyperandrogenism and consequently AMH levels, as a result of ovulation induction in these patients.
Aims: The study aimed to determine the impact of therapy with the insulin sensitizers, Metformin and Myoinositol, on Anti-Mullerian hormone and to determine its association with insulin resistance in women with polycystic ovary syndrome.
Material and methods: A prospective, randomized, clinical study was conducted at the University Clinic for Endocrinology, Diabetes and Metabolic Diseases in Skopje, in the period 2022/2023. The study included 64 women, aged 18 to 40 years, diagnosed with polycystic ovarian syndrome, according to the 2003 Rotterdam criteria. Patients were divided into two groups: group A received Metformin 1500 mg XR, and group B was on Myoinositol 2 gr TID, during 6 months. The parameters BMI, AMH, HOMA-IR (homeostasis model assessment index) and FAI (free androgen index) were monitored.
Results: After completion of treatment, a significant decrease in AMH levels was observed in both groups - group A (p=0.0012) and group B (p=0.0014). This was accompanied with decline in HOMA IR and FAI values after the end of treatment in both groups.
Conclusion: In line with the results obtained, AMH could be considered a marker of the efficacy of treatment with insulin sensitizers in PCOS.
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