CONGENITAL CYSTIC ADENOMATOID MALFORMATION OF THE LUNGS: A CASE REPORT

Authors

  • Sanja Ristovska University Clinic for Gynecology and Obstetrics, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Snezana Jancevska University Clinic for Gynecology and Obstetrics, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
  • Lazo Jovceski University Clinic for Pediatric Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia

DOI:

https://doi.org/10.53582/a97qr940

Keywords:

newborn, congenital cystic adenomatoid malformations

Abstract

Congenital cystic adenomatoid malformations (CCAM) of the lung are a rare congenital disorder. The prevalence of this condition is 9 per 100,000 births, with a slight predominance in males. Most cases present clinically in the neonatal period, but may remain asymptomatic until adulthood. The etiology of CCAM is not fully understood. Fetal cystic changes of the lungs are detected prenatally by ultrasound, and postnatally, the definitive method is chest computed tomography (CT) or magnetic resonance imaging (MRI). Resection of CCAM is recommended due to the risk of malignancy. We present the case of a term-male hypotrophic newborn, in whom cystic changes of the right lung were detected prenatally. The chest X-ray and CT scan postnatally confirmed right-sided congenital adenomatoid cysts. At the age of 2 months, the infant underwent surgical resection of cystic changes, and CCAM type 1 was histologically proven.

References

1. Abreu SM, Braga I, Sobreiro SJ, Correia PJ, Gonçalves A. Congenital cystic adenomatoid malformation of the lung: diagnosis in a preadolescent. J Pediatr Neonat Individual Med 2023; 12(1): e120128. doi: 10.7363/120128.

2. El Amraoui W, Bentalha A, Hamri H, Es-Chrif El Kettani S, El Koraichi A. Congenital cystic adenomatoid malformation - dangers of misdiagnosis: a case report. J Med Case Rep 2017; 11(1): 212. doi: 10.1186/s13256-017-1349-5.

3. Sahu S, Muthuvel S, Naware SS, Dhavala SS. Congenital cystic adenomatoid malformation of lung. Med J Armed Forces India 2008; 64: 268‑269. doi: 10.1016/S0377-1237(08)80113-X.

4. Hansen T, Cooper T, Weisman L. Congenital diseases affecting the lung parenchyma. In: Contemporary Diagnosis and Management of Neonatal Respiratory Diseases. Newton, PA: Handbooks in Health Care Co. 1995: 164-179.

5. Chikkannaiah P, Kangle R, Hawal M. Congenital cystic adenomatoid malformation of lung: Report of two cases with review of literature. Lung India 2013; 30(3): 215-218. doi: 10.4103/0970-2113.116272.

6. Gosain R, Motwani R. Congenital cystic adenomatoid malformation of the lung: a case report with embryological review. Anat Cell Biol 2022; 55(2): 264-268. doi: 10.5115/acb.21.260.

7. Keidar S, Ben-Sira L, Weinberg M, Jaffa AJ, Silbiger A, Vinograd I. The postnatal management of congenital cystic adenomatoid malformation. Isr Med Assoc J 2001; 3(4): 258-261. PMID: 11344837.

8. Blatter JA, Finder JD. Congenital Disorders of the Lung, Nelson Textbook of Pediatrics 20th, New York, Boston, London 2016; 2057-2061.

9. Gardikis S, Didilis V, Polychronidis A, Mikroulis D, Sivridis E, Bougioukas G, et al. Spontaneous pneumothorax resulting from congenital cystic adenomatoid malformation in a pre-term infant: case report and literature review. Eur J Pediatr Surg 2002; 12(3): 195-198. doi: 10.1055/s-2002-32733.

10. Ch'in Y, Tang M. Congenital adenomatoid malformation of one lobe of a lung with general anasarca. Arch Pathol Lab Med 1949; 48(3): 221-229. PMID: 18137795.

11. Stocker JT. Congenital pulmonary airway malformation: a new name and an expanded classification of congenital cystic adenomatoid malformation of the lung. Histopathology 2002; 41(Suppl 2): 424-431.

12. Shamas AG, Bohara K. Congenital cystic adenomatoid malformation of the lung (CCAM), a retrospective clinical audit and literature review in a tertiary centre in Scotland over a period of 14 years. J Obstet Gynaecol 2017; 37(1): 19-24. doi: 10.1080/01443615.2016.1196480.

13. Cass DL, Olutoye OO, Cassady CI, Moise KJ, Johnson A, Papanna R, et al. Prenatal diagnosis and outcome of fetal lung masses. J Pediatr Surg 2011; 46(2): 292‑298. doi: 10.1016/j.jpedsurg.2010.11.004.

14. Annunziata F, Bush A, Borgia F, Raimondi F, Montella S, Poeta M, et al. Congenital Lung Malformations: Unresolved Issues and Unanswered Questions. Front Pediatr 2019; 7: 239. doi: 10.3389/fped.2019.00239.

15. Badour M, Hussain B, Hammed A, Sawssan Ali, Falyon S. A rare case of congenital cystic adenomatoid malformation: Mimics pneumonia manifestations. Ann Med Surg (Lond) 2021; 66: 102433. doi: 10.1016/j.amsu.2021.102433.

Downloads

Published

2026-06-18

Issue

Section

Case Reports